Food Safety

Any RASV to control any disease of farm animals reduces likelihood for Salmonella transmission through the food chain to humans – and therefore enhance food safety.

Coccidiosis

Coccidiosis is a devastating disease in poultry with several Eimeria species important for most of the morbidity and mortality in the poultry industry. We are using several RASV platforms toward developing a vaccine to prevent this disease and eliminate the need to rely on expensive coccidiostats that also result in parasite resistance.

For more information see:

Konjufca, V., S. Y. Wanda, M. C. Jenkins, and R. Curtiss III. 2006. A recombinant attenuated Salmonella enterica serovar Typhimurium vaccine encodingEimeria acervulina antigen offers protection against E. acervulina challenge. Infect. Immun. 74:6785-6796.

Konjufca, V., M. Jenkins, S. Wang, M. D. Juarez-Rodriguez, and R. Curtiss III. 2008. Immunogenicity of recombinant attenuated Salmonella enterica serovar Typhimurium vaccine strains carrying a gene that encodes Eimeria tenella antigen SO7. Infect. Immun. 76:5745-5753.

C. jejuni

Campylobacter jejuni is a commensal in poultry but is often transmitted through the food chain to cause diarrheal disease in humans at a level equal to or greater than the food transmitted Salmonella causing diarrheal disease in humans. An RASV delivering antigens conferring protective immunity to C. jejuni would thus represent an important Food Safety vaccine for poultry.

For more information see:

Theoret, J. R., K. K. Cooper, B. Zekarias, K. L. Roland, B. F. Law, R. Curtiss III, and L. A. Joens. 2012. The Campylobacter jejuni Dps homologue is important for in vitro biofilm formation and cecal colonization of poultry, and may serve as a protective antigen for vaccination. Clin. Vaccine Immunol. 19:1426-1431.